Mail App Not Opening Mac
I've been trying to change the default email application on my Macbook Pro unsucessfully.

On your Mac, open System Preferences (from the Apple menu at the top-left of the screen), or use Terminal. Click Users & Groups; Click the Login Items tab; Here you will see the apps that will open automatically at login. If Mail is there, you can stop it from opening automatically, select and and click the minus icon to remove it.

I'm using Outlook 2016 on my Mac and would like to use it for all my email as I use Safari to login to my personal web mail. On Yosemite I would open Mail, go to Preferences and change the Default Email Application in the menu to Outlook. I can do that on El Capitan but as soon as I close preferences and open it again the setting is back to Mail.
Mail App Not Loading Emails Mac
Make not of the results, then restart the computer and try opening the Mail app again. Test the Mail app in a new user account. The following article provides information on why testing in another user account can be helpful, as well as walks you through how to set up a new account: How to test an issue in another user account on your Mac. If you can’t open Mail on your Mac. If you try to open a version of the Mail app that can’t be used on your Mac, an alert message is displayed. Make sure the version of Mail you’re trying to open is located in the Applications folder. In the Finder, click Applications in the sidebar, then double-click Mail.
On older versions of Outlook you could open the app and go to preferences and check a box there to set it as the default mail app but that setting seems to have been removed.
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Mac Apps Won't Open
64 bit apps mac. Has anyone else experienced this?